Scientist, In vivo Pharmacology, Oncology Targeted Discovery

Scientist, In vivo Pharmacology, Oncology Targeted Discovery

Are you passionate about oncology research and development? Do you want to make a real impact by turning scientific ideas into life-changing medicines? Join AstraZeneca as a Scientist in cancer pharmacology within our Oncology Targeted Discovery group in Waltham, Massachusetts. Here, you'll be a vital part of a team dedicated to advancing in vivo pharmacology support. Your expertise will help establish mouse models and assay systems, delivering crucial datasets that drive our drug discovery process forward.

Accountabilities:

In this laboratory-based role, you'll design, execute, and analyze in vivo and ex vivo experiments to evaluate the function and mechanisms of promising oncology drug candidates. You'll generate high-quality data to support cross-functional project teams, working closely with senior scientists and project leaders. Your contributions will be essential to the progress of our oncology research programs and scientific publication goals. As an organized and motivated scientist, you'll enhance your knowledge in tumor biology, pharmacology, and cancer modeling while collaborating in a dynamic research environment.

Essential Skills/Experience:

- You must hold a BS/MS with at least three years of relevant research experience in biology, pharmacology, or a related discipline.
- You should have hands-on experience with in vivo oncology models, which could include subcutaneous xenograft, patient-derived xenograft (PDX), syngeneic, or humanized mouse models.
- Experience performing in vivo pharmacology studies in these models - covering areas such as dose-finding tolerability, PK/PD, and basic efficacy studies - is required, as is familiarity with standard dosing techniques including intravenous (IV), intraperitoneal (IP), and oral gavage (PO).
- Your laboratory skill set includes foundational in vitro techniques such as cell culture, molecular biology, immunoblotting, flow cytometry, or ELISA/MSD.
- You are able to collect, document, and clearly communicate experimental data, with an understanding of its relevance to the broader objectives of drug discovery.
- You show initiative and can work both independently and collaboratively as part of a team.
- Strong verbal and written communication skills are essential, as is the ability to follow guidance from senior team members.

Desirable Skills/Experience:

- Previous experience in the biotechnology or pharmaceutical industry, particularly in oncology-focused roles, is a plus.
- Familiarity with in vivo studies involving antibody-drug conjugates (ADCs), or with mouse models resistant to cancer therapies, will be advantageous.
- Additional experience with syngeneic mouse models relevant to immuno-oncology, participation in multi-spectral flow cytometry studies, or assisting with the training of junior staff, will also be beneficial.
- Some understanding of the industrial drug discovery process is desirable.

At AstraZeneca, we are driven by curiosity and determination to transform the practice of medicine in Oncology. Our team is at the forefront of applying science to create new possibilities for patients living with cancer. With one of the broadest Oncology pipelines in the industry, we offer opportunities to work with novel drugs and innovative approaches. We foster a collaborative environment where diverse perspectives are valued, empowering everyone to step up and innovate. Join us on our mission to make paradigm shifts in treatment options and improve patient outcomes worldwide.

Ready to make a difference? Apply now and be part of our journey to change the future of cancer treatment!

Date Posted

07-Jul-2025

Closing Date

30-Aug-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.